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At Gilead, we’re creating a healthier world for all people. For more than 35 years, we’ve tackled diseases such as HIV, viral hepatitis, COVID-19 and cancer – working relentlessly to develop therapies that help improve lives and to ensure access to these therapies across the globe. We continue to fight against the world’s biggest health challenges, and our mission requires collaboration, determination and a relentless drive to make a difference.

Every member of Gilead’s team plays a critical role in the discovery and development of life-changing scientific innovations. Our employees are our greatest asset as we work to achieve our bold ambitions, and we’re looking for the next wave of passionate and ambitious people ready to make a direct impact.

We believe every employee deserves a great leader. People Leaders are the cornerstone to the employee experience at Gilead and Kite. As a people leader now or in the future, you are the key driver in evolving our culture and creating an environment where every employee feels included, developed and empowered to fulfil their aspirations. Join Gilead and help create possible, together.

Job Description

Job Description:

The Protein Engineering group is a specialized team within the Protein Therapeutics department that is responsible for the optimization and engineering of large molecule drug candidates. We seek a highly motivated Senior Research Associate I to support a multidisciplinary team with capabilities in protein engineering, cloning, expression, purification and characterization of large molecule drug candidates to develop novel biologics for clinical development and to create cutting-edge technologies driven by computational protein design. The successful candidate will assist with the translation of in silico designs to the wet lab.

Essential Duties and Job Functions:

In this laboratory-based role, the successful candidate will support efforts to optimize large molecule therapeutics. The candidate will express and purify large panels of protein designs, as well as implement biophysical and biochemical assays to evaluate new technologies and characterize biologics for diverse target classes. Additional job requirements:

Enable rapid optimization of novel antibody and protein therapeutics through iterative design, build, test, and learn cycles.

Advance engineering technologies to enable large molecule drug development.

• Characterize the binding and functional properties of antibodies, multispecifics, immunocytokines, and other biologics.

• Maintain familiarity with scientific literature and independently design, execute, analyze, and interpret experiments.

• Effectively communicate and present project goals and experimental findings to diverse audiences.

• Organize and execute multiple projects in a collaborative team setting.

• Thrive in a fast paced, data-driven and scientifically rigorous environment.

• Maintain compliance with company policies and record keeping.

Knowledge, Experience and Skills:

Applicants must have a B.S./M.S. in molecular biology, biochemistry, structural biology or a related field, with a minimum of 2+ for B.S./ 0+ for M.S. years of relevant professional experience. An ideal candidate will have experience in most of the following areas:

• Experience in laboratory techniques supporting structural biology and molecular biology.

• Familiarity with structure-based protein engineering and design principles.

• Knowledge and understanding of molecular biology techniques: cloning, plasmid preparation, vector design, and mutagenesis.

• Proficient in mammalian cell culture, protein expression

• Experience with protein purification using an AKTA Pure/Avant for SEC, IEX, HIC, mixed mode, and affinity chromatography. Experience with different multispecific formats, immunocytokines, and fusion proteins preferred.

• Excellent communication and organizational skills.

• Ability to multi-task and self-motivated with excellent problem-solving skills.

Preferred qualifications:

• Experience with biochemical assays and quantitative analysis of protein-protein binding interactions (e.g. FACS, ELISA, Octet, Carterra).

• Familiarity with computational design tools such as Rosetta, ProteinMPNN, MOE, Schrodinger, etc is a plus

The salary range for this position is: $92,820.00 - $120,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

• Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact ApplicantAccommodations@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' (https://www.eeoc.gov/employers/eeo-law-poster) poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site (https://www.myworkday.com/gilead/d/inst/13102!CK5mGhIKBggDEMenAhIICgYI1A0QtgI/cacheable-task/2997$2151.htmld#backheader=true) to apply for this job.

Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California.